I. Yu. Belov

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Diffuse progressive atrophy of the bronchial epithelium and mucosa are the main changes detected in the biopsy specimens of large bronchi in lung cancer. Unstability of the bronchial epithelium in lung tumors (alternating atrophy, metaplasia, hyperplasia, and dysplasia) is described.
Pathomorphological examination of large bronchi in patients with occupational diseases, lung cancer, and in subjects exposed to radiation revealed structural and functional heterogeneity of the epithelium: the presence of focal atrophy, metaplasia, hyper- and dysplasia in the same biopsy specimen. This phenomenon was termed as instability of the epithelium.(More)
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