I V Silkina

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The influence of afobazole on the accumulation of free radical oxidation products (reactive oxygen species, ROS) and on the activity of antioxidative enzyme catalase was studied in striatum and cortex of rats under cerebral ischemia damage conditions. Afobazole showed a tendency to decrease the extent of ROS accumulation in the cortex. In striatum, the(More)
The role of GABAergic mechanisms in realization of the effects of afobazole and picamilon on the cerebral circulation was studied in rats. It is found that the cerebrovascular effect of afobazole significantly decreases on the background of the GABA receptor antagonists bicuculline and picrotoxin. This is evidence of an important role of the GABA system in(More)
The selective anxiolytic drug afobazole administered in a dose of 5 mg/kg increased the cerebral blood flow in rats. The effect was more pronounced in rats with global reversible cerebral ischemia than in intact animals. The ischemia model was caused by occlusion of both common carotid arteries for 120 min with simultaneous reduction of the arterial(More)
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