I. V. Malinovskaya

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The delayed effect of food-derived opioid peptides (exorphins) after chronic administration on postnatal days 1–14 on the learning of albino rat pups has been studied. Heptapeptide YPFPGPI (β-casomorphin-7), pentapeptide YPLDL (rubiscolin-5) and pentapeptide YPISL (exorphin C) improved the development of the conditioned foraging reflex in a complex maze.(More)
Systemic administration of β-casein heptapeptide β-casomorphin-7 (YPFPGPI, 1 mg/kg daily) to 10–23-day-old albino rat pups produced delayed anxiolytic effects, which were more pronounced in female than in male rats. Experimental findings confirm our assumption on the important role of nutritional opioids in brain development in newborn mammals.
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