I. V. Batueva

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Patch-clamp recordings in a whole-cell mode were performed on dorsal sensory cells enzymatically isolated from the spinal cord of two lamprey species, Ichthyomyzon unicuspis and Lampetra fluviatilis. The voltage-activated currents through calcium channels were analysed. GABA and the specific GABA(B) receptor agonist baclofen reduced the peak amplitude of(More)
Potential-gated currents in the membranes of enzymatically isolated neurons from the lamprey spinal cord were investigated using the whole cell variant of the patch-clamp technique. As it was revealed the main currents underlying action potential (AP) in the dorsal sensory cells as well as in branched cells are inward Na(+)- and outward K(+)-currents.(More)
Effects of inhibitory mediators on the membranes of isolated lamprey spinal cord neurones were investigated by means of whole-cell recording and concentration clamp techniques. Glycine and gamma-aminobutyric acid (GABA) applications evoked desensitizing chloride currents. The concentrations at half-maximum effects were 16 microM for glycine- and 1.5 mM for(More)
delta-Baclofen reduced the peak amplitude of the barium current in the DSCs from Lunicuspis and L.fluviatilis. The membrane conductance was not altered either by baclofen or GABA. The reducing effect could be abolished with delta-aminovaleric acid or 2(OH)saclofen. The data obtained suggest presence of the GABAB receptors in the DSC membranes. Functional(More)
Studies were performed on spinal neurons from lampreys isolated by an enzymatic/mechanical method using pronase. The effects of 100 μM serotonin (5-HT) on membrane potential oscillations induced by a variety of excitatory amino acids were studied. 5-HT was found to depolarize branched cells (presumptive motoneurons and interneurons) by 2–6 mV without(More)
The experiments reported here showed that application of serotonin (5-hydroxytryptamine, 5-HT) (100 μM) did not induce any significant current through the membranes of any of the spinal neurons studied (n= 62). At the same time, the membranes of most motoneurons and interneurons (15 of 18) underwent slight depolarization (2–6 mV) in the presence of 5-HT,(More)