I. Ustinovitch

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BACKGROUND & OBJECTIVES immunocompromized adults. Approximately 50 per cent of the GBS strains carry and express the gene of BAC antigen which is capable to bind IgA. Gene encoding for the BAC antigen has been cloned and sequenced but actual IgA binding region on the protein has not been detected. The aim of the present work was to localize the region of(More)
Group B streptococci (GBS) are a leading cause of neonatal sepsis and meningitis. Besides the type-specific capsule, which is considered to be a major virulence factor of the species, some proteins are believed also to be virulence determinants and have been found to elicit protective immunity. In the present work, the genes for two surface proteins, the(More)
Different fragments of thebac gene coding for the IgA-binding protein were cloned, sequenced and expressed inE. coli. Cloning was accomplished after amplification of different parts of the gene by PCR. The 1.5-kb fragment of the gene was cloned using plasmid pBluescript. This fragment coded for the 45-kDa protein with the stable expression of IgA binding.(More)
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