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A 38-year-old female died 6 years after the onset of what was, clinically and histopathologically, consistent with neuro-Behcet's disease. Pathologically the cerebrum showed severe atrophy. The main changes were observed in the grey and white matter, the diencephalon and the basal ganglia by light microscopy. All these changes originated in softenings(More)
In the present study, thirty schizophrenics who showed low blood pressure and low voltage fast EEG at the onset of the disease were selected from many schizophrenics. As a control group, 50 schizophrenics without any abnormal findings in blood pressure and EEG were examined. The experimental group showed a remarkable improvement after using Haloperidol and(More)
Peripheral nerve and muscle of patients with hemiatrophy were biopsied and examined by means of light and electron microscope. The unmyelinated nerve fibers decreased in number and remaining fibers were atrophic with irregular shape and high electron density, while myelinated nerve fibers slightly decreased in number. The Schwann cells enveloping nerve(More)
Wistar strain male rats (body weight 180 g) were given 0.5 mg beta-methasone per kilogram of body weight orally each day for 180 days. Histopathologically, remarkable changes occurred only in the hypothalamus and thalamus. The mitochondria showed vacuolar degeneration not only in the nerve cells but also in the nerve fibers and glia cells, and the Golgi(More)
Ten adult male rats were administered orally with thyroideum siccatum every day to produce a hyperfunctional state of thyroid hormone. They were examined electron microscopically for the fine structure of the brain. Clinically, experimental rats lost in weight, manifested a hyperactive, irritative attitude, and were in an aggressive state. Electron(More)
Numerous inclusions were diffusely observed in the neurons and glial cells in the cerebral cortex of a patient with progressive dementia. These inclusions were initially produced by rough ER in the cells and gradually enlarged destroying the rough ER membranes. The nature of these inclusions was neutral mucopolysaccaride including protein histochemically.(More)
The cerebral cortex taken post mortem from a case of Alzheimer's disease was examined especially with regard to the relation between blood vessels and senile plaques. Many senile plaques had central cores, composed of such matter as degenerated blood vessels and basement membranes with abundant amyloid fibrils. The components of senile plaques seemed to be(More)
Twenty-two patients who had low blood pressure with hallucinatory and delusional states were examined. Nineteen cases showed low voltage fast waves in EEG. By treatment with haloperidol the symptoms as well as the blood pressure and EEG showed improvement. From the above findings, the hallucinatory and delusional states observed in this study may have a(More)
A 29-year-old male characterized by progressive dementia has been described. Histopathologically, the changes obtained were as follows: 1) Some atrophic nerve cells contained homogeneous round or oval intraplasmic inclusions which could be stained with periodic acid-Schiff and coupled tetrazonium. From these examinations the inclusions consisted of neutral(More)
The brains of six cases of chronic alcoholics without arteriosclerosis and the other diseases were examined histopathologically. The results obtained were as follows: there were chronic nerve cell sclerosis and deletion with slightly increased glial cells in the cortex of the cerebrum, hypothalamus, mamillary body, amygdal body, dentate endplate of Ammon's(More)