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BACKGROUND Pili were recently recognized in Streptococcus pneumoniae and implicated in the virulence of this bacterium, which led to the proposal of using these antigens in a future pneumococcal vaccine. However, pili were found to be encoded by the rlrA islet that was not universally distributed in the species. We examined the distribution of the pilus(More)
BACKGROUND Streptococcus pneumoniae can be carried asymptomatically in the nasopharynx of its human host but can also cause a wide range of infections. A role for pneumococcal phase variants in the different lifestyles of this bacterium has been suggested but no systematic survey of the colony phenotypes of isolates associated with human infections has been(More)
Kyotorphin (KTP) is an endogenous peptide with analgesic properties when administered into the central nervous system (CNS). Its amidated form (l-Tyr-l-Arg-NH2; KTP-NH2) has improved analgesic efficacy after systemic administration, suggesting blood-brain barrier (BBB) crossing. KTP-NH2 also has anti-inflammatory action impacting on microcirculation. In(More)
This paper addresses the mechanisms behind selective endothelial permeability and their regulations. The singular properties of each of the seven blood-tissues barriers. Then, it further revisits the physical, quantitative meaning of permeability, and the way it should be measured based on sound physical chemistry reasoning and methodologies. Despite the(More)
Travel times of 11,612 Pn arrivals collected from 7675 earthquakes are inverted to image the uppermost mantle velocity and anisotropy structure beneath the southern half of the Iberian Peninsula and surrounding regions. Pn phases are routinely identified and picked for epicentral distances from 200 to 1200 km. The method used in this study allows(More)
BACKGROUND Pseudomonas aeruginosa is an important human opportunistic pathogen responsible for fatal nosocomial infections worldwide, and has emerged as a relevant animal pathogen. Treatment options are dramatically decreasing, due to antimicrobial resistance and the microorganism's large versatile genome. Antimicrobial resistance profiles, serotype(More)
Accuracy and speed instructions have been recently and successfully used to determine the locus of confidence judgments for detection and discrimination tasks (Baranski & Petrusic, 1998; Petrusic & Baranski, 2000). No such research has been done using magnitude estimation. This paper studies, using an absolute magnitude estimation task and four experimental(More)
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