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We present calculations of the polarization energy required when a multipolar source enters a transmembrane ion channel. The polarization energy for polar, but uncharged, sources is nearly independent of channel length if the length/diameter ratio is greater than 1.25; however, it is strongly dependent on channel radius. All significant changes in the(More)
A shortened analog of gramicidin A has been shown by Urry et al. (Biochim. Biophys. Acta 775, 115-119) to have lower conductance than native gramicidin A. They argue this suggests that the major current carrier is the doubly occupied channel. A different perspective is presented here. Channel formation does not alter bilayer width. In a shortened channel an(More)
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