I. S. Sazykin

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A comparative H2O2-luminol- and Fe(II)-induced chemiluminescence analysis of extracts of two strains of marine oil oxidizing bacteria Actinetobacter calcoaceticus cultivated either in the presence or absence of oil was carried out. Effects of these extracts on E. coli MG1655 biosensor (pSoxS-lux) were studed. Activation of H2O2-induced chemiluminescence in(More)
The plastoquinone derivative 10-(6′-plastoquinonyl)decyltriphenylphosphonium (SkQ1) has the ability to scavenge superoxide anion radical. This ability is manifested both in vitro and in vivo in experiments with the bacterium Escherichia coli. The protective effect of SkQ1 in vivo significantly exceeds that of ascorbic acid.
BIn the legend of figure 3 of this article, «superoxide anion radical» was replaced by «hydrogen peroxide». The correct figure legend reads as follows: Intensity of hydrogen peroxide generation (measured with lucigeninactivated CL) upon incubation of oil-biodegrading microorganisms within 30 days in basic mineral salt medium with addition of yeast extract(More)
Pathogenic bacteria and fungi eventually develop resistance to existing drugs, and therefore, we need constant development of new drugs. The research is aimed at addressing fundamental scientific problems-the search for new biologically active compounds among several benzofuroxan-containing 'hybrid' products. N-substituted naphthalimides were chosen as a(More)
The research on the structure and role of bacterial cytochromes P450 are summarized in this review. We consider the organizational features of these enzymes, cytochrome-catalyzed reactions, the distribution of cytochromes among prokaryotes, and their functions in bacterial cells. We cite the data on cytochrome genes and the regulation of their expression in(More)
New derivatives of sterically hindered phenols were obtained. Their DNA-protective activity under UV irradiation was studied. The experimental results showed that the investigated compounds protected genetic material from both direct UVB radiation and reactive oxygen species generated in the cell by it. The new compounds were promising components for(More)
The lower Don River in the south of the European part of Russia was studied to determine the concentration, spatial distribution, and sources of 19 polycyclic aromatic hydrocarbons (PAHs) in surface sediments. Total PAH concentrations ranged from 14.2 to 529 ng/g-dw. Sedimentary PAH concentrations were higher in the delta of the Don River and in the(More)
Expression of antioxidant enzymes [superoxide dismutase (SOD) and catalase] and generation of reactive oxygen species (ROS) in the presence of various hydrocarbons were investigated in two strains of hydrocarbon-degrading microorganism Acinetobacter calcoaceticus isolated from water (VKPM B-10353) and bottom sediment (EMBM-06). Upon biotransformation of(More)
New compounds containing both benzofuroxan and benzothiazole scaffolds were synthesized through electrophile/nucleophile combination of nitrobenzofuroxan derivatives and 2-mercapto- or 2-aminobenzothiazole derivatives and their biological effect on the natural strain Vibrio genus and different bacterial lux-biosensors was studied. Among all the compounds(More)
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