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The effect of amphetamine and l-dopa was compared in 22-hr food- and water-deprived rats. Amphetamine produced marked anorexia, and l-dopa significantly reduced food intake at 200 mg/kg. Following pretreatment with RO 4-4602, a decarboxylase inhibitor, 100 mg/kg of l-dopa, a dose that did not significantly affect eating, produced marked anorexia. The(More)
The requirement for calcium in membrane stabilization and the functioning of neuronal systems is well established [ 1,2], particularly in excitation coupling m~h~isms [3,4] and in the regulation of hormone-receptor interactions[5], but the role of calcium in the mechanism of action of opiates has been investigated only recently. Morphine and calcium(More)