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Uracil-DNA glycosylase, the enzyme responsible for the removal of uracil from DNA (1), is directly involved in mutation avoidance (2). Indeed, it is likely to prevent transition mutations by removing uracil that results from deamination of cytosine. It has been proposed that the removal of misincorporated uracil by uracil-DNA glycosylase also plays an(More)
We have previously shown that basic fibroblast growth factor (bFGF) inhibits the FSH-induced differentiation of cultured rat granulosa cells, as manifested by prominent reduction of the LH receptor expression. We now investigate the possible sites and mechanism of action of bFGF. Whereas bFGF decreased the cAMP formation induced by FSH, it enhanced the cAMP(More)
The generalized mismatch repair system of Streptococcus pneumoniae (the Hex system) can eliminate base pair mismatches arising in heteroduplex DNA during transformation or by DNA polymerase errors during replication. Mismatch repair is most likely initiated at nicks or gaps. The present work was started to examine the hypothesis that strand discontinuities(More)
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