I. Reilly

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In this paper, we continue the study of generalized closed sets in a topological space. In particular, we study the question when some classes of generalized closed sets coincide. A new class of spaces, the class of sg-submaximal spaces, is also introduced. Characterizations of extremally disconnected spaces and sg-submaximal spaces are established via(More)
The ability of blast cells to grow autonomously and to produce autostimulatory growth factors has been investigated in 25 consecutive patients with AML. An autostimulatory index (ASI) was calculated (no. of colonies without CSF divided by no. of colonies with CSF) and patients classified into four groups: Group 1 (n = 3): non-growers; Group 2 (n = 4):(More)
We have studied peripheral blood blast cells from a patient with acute myeloblastic leukemia (AML) whose cells proliferated autonomously at high cell density, but only in the presence of adherent cells. At low cell density in suspension culture and in a clonogenic assay, blast cell growth was stimulated by recombinant granulocyte macrophage colony(More)
The blast cells from some patients with acute myeloblastic leukemia (AML) proliferate autonomously in vitro. We have previously identified four groups of AML blasts based upon their growth characteristics in vitro, in particular the degree of autonomous growth. We have now measured the production of granulocyte-macrophage colony-stimulating factor (GM-CSF)(More)
The role of interleukin-1 (IL-1) as a regulator of the autonomous growth of the blast cells of acute myeloid leukaemia (AML) has been studied on samples isolated from 15 patients. In nine out of 10 patients with evidence of partial autonomous blast cell growth. IL-1 further stimulated cell growth in both suspension culture and in a clongenic assay. IL-1(More)
Topology has its own specialised language. Where did this come from? What are the differences in the language of topology when it is expressed in English, Spanish, Mandarin, Czech or Turkish? Does topology itself change when expressed in different languages? What effect has language had on the development of topology? Does the language of the topologist(More)
In long-term culture (LTBMC) of marrow from patients with myelodysplastic syndromes (MDS) abnormal patterns of growth, dysplastic cell morphology and cytogenetic changes present at initiation of culture persisted, providing a model in which to investigate the effects of hemopoeitic growth factors. In this model, rGM-CSF added weekly (100 µ/ml) failed to(More)
The role of cellular interactions in stimulating leukemic cell proliferation was studied in AML. When peripheral blood blasts were cultured in suspension in flat-bottomed vessels at low cell numbers (15.6-500 x 10(3)/ml), the rate of DNA synthesis [( 3H]thymidine incorporation) was proportional to cell density. When cells were cultured under otherwise(More)