I. N. Marks

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John Sydney Edkins was born in London in 1863. After gaining two open scholarships, he attended Caius College, Cambridge and studied physiology under the tutelage of J.N. Langley and M. Foster. During this period he published on the chemical nature of pepsinogen with Langley. After qualifying as a medical doctor, he worked in Manchester before returning to(More)
Our purpose was to study the effect of Helicobacter pylori (HP) on mucosal protein fractionalsynthesis (MPFS) and growth factor expression. 14 C-leucine incorporation, and TGF-α, β-FGF, andEGF-receptor levels were assessed in gastric and duodenal mucosa in 20 patients with HP-associatedgastritis and repeated after treatment of the gastritis, with or without(More)
In order to investigate the role of sucralfatein active ulcerative colitis, 60 patients wererandomized to receive either sucralfate enemas (20 g/100ml) or methylprednisolone enemas (20 mg/100 ml). The enemas were administered twice daily for oneweek, and then once daily for three weeks. Clinicalevaluation was documented at entry and at two weeks andfour(More)
In order to investigate whether chronic duodenalulcer disease is a consequence of disturbed mucosalturnover and growth factor expression, we studied 16patients with duodenal ulcers before, during, and after endoscopic healing with lansoprazole orsucralfate. Before treatment, gastric fundal and antralmucosal protein turnover rates were higher in patientsthan(More)
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