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Clinicobacteriological examination was carried out in 31 patients with the crush syndrome (CS) and extensive damage to the soft tissues in combination with bone fractures complicated by wound infection. Inadequate surgical treatment in the early periods after the trauma (complete closure of the wound, making small incisions of the involved skin and(More)
The efficacy of eremomycin, a new glycopeptide antibiotic, was studied on a model of antibiotic-associated colitis in golden hamsters. The colitis was induced by intraperitoneal or intragastric administration of lincomycin. In a dose of 100 mg/kg administered orally once a day for 5 days eremomycin protected the animals from the lincomycin-induced colitis:(More)
Erythrocytic immunoglobulin diagnostic reagent for detecting Cl. perfringens enterotoxin in the indirect hemagglutination test has been obtained. The diagnostic reagent has been prepared on the basis of antibodies of Cl. perfringens enterotoxin with the use of acroleinized tanned sheep red blood cells. The indirect hemagglutination test with this reagent is(More)
Morphological studies carried out in the igated loop of the rabbit small intestine, used as a model, have revealed that the action of the enterotoxins of C. perfringens type A reference strain and C. perfringens type A strains isolated in the USSR on the intestinal mucosa is absolutely identical. This action is manifested by the destruction of epithelial(More)
A method for isolation of the ribosomal fraction (RF) from the cytoplasm of type-A C. perfringens strain BP6K was developed and its chemical and antigenic properties characterized. RF has been found to possess protective properties: two subcutaneous immunizations of mice with RF preparations adsorbed on Al(OH)3 in doses of 250 and 500 micrograms (dry(More)