I M Werkman

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Twelve healthy white male volunteers participated in a randomized double-blind cross-over study to compare the bio-availability of four brands of furosemide marketed in the RSA. A 40 mg tablet of each of the following formulations, purchased at random, was administered: Aquasin; Furetic; Lasix; and Puresis. Blood specimens were taken up to 5 hours and urine(More)
Ten hypertensive patients completed a trial lasting 12 weeks to measure the effect of long-term treatment with piretanide, a new, powerful 'loop' diuretic, on total body potassium (TBK). After 2 weeks of placebo treatment, they received 6 mg piretanide twice daily. This dose was increased to 6 mg 3 times a day if blood pressure was not satisfactorily(More)
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