I. M. Ladenbauer-Bellis

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Short-term incubations of intact canine articular cartilage slices with prostaglandins E1 and E2 caused significant losses of hexosamine from cartilage matrix compared to controls. Chloroquine, an inhibitor of DNA primer, prevented this prostaglandin-induced hexosamine depletion. These data suggest that E-prostaglandins may degrade articular cartilage(More)
Using a computerized pendulum device for delivery of a moderate, reproducible impact on the surface of canine femoral cartilage, the lipids of the cartilage were analyzed by gas chromatography, and a four-fold increase in arachidonic acid was found in the phospholipid pool, as compared with controls. This is the first evidence presented thus far which(More)
Purified xenogeneic cartilage matrix components, including proteoglycan subunits, chondroitin 4 sulfate, and chondroitin 6 sulfate, were inoculated into the knee joint of rabbits, and local as well as systemic responses were evaluated. proteoglycan was associated with synovial hyperplasia and infiltrates of eosinophils and lymphocytes and with rising titers(More)
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