I. M. Antonikov

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Secretory granules and, in particular, synaptic vesicles (SV) of neurons contain a protein pump (H+-ATPase) in their membranes. During ATP hydrolysis on the outer side of the membrane H + ions are actively pumped inside SV (or the secretory granules) and the pH within the granules reaches 5.0-5.3. The functioning of the H+-pump of SV membrane may be(More)
!. V.N. Anders and D. D. Orlovskaya, Zh. Nevropatol. Psikhiat., 82, 1071 (1982). 2. N.N. Vakolyuk, Stereotaxic Atlas of the Human Brain [in Russian], Kiev (1979). 3. S.D. Zaiko, N. I. Sokolova, T. P. Klyushnik, and G. Sh. Burbaeva, Biokhimiya, 49, 355 (1984). 4. P.J. Marangos, A. Parma, and F. K. Goodwin, J. Neurochem., 31, 727 (1978). 5. P.J. Marangos and(More)
The properties of the transmembrane potential (TMP) of synaptosomes (Sin) from the rat brain cortex were studied by means of the fluorescent probe I-anilinonaphthalene-8-sulfonate (ANS). The fluorescent emission that increased at 464 nm (lambda ex = 365 nm) after addition of valinomycin to synaptosomes was considered as the reflection of Sin(More)
During the development of epileptic activity (EpA) induced by various methods, intraneuronal Ca 2+ metabolism is disturbed [2, 8, 11], and this is an important mechanism of the initiation and formation of EpA. Inflow of Ca 2+ into nerve terminals and axons takes place mainly via voltage-dependent Ca channels. Recently, therefore, to abolish EpA, various(More)
The transmembrane potential (TMP) of synaptosomes isolated from the rat cerebral cortex was studied with the aid of 1-anilinonaphthalene-8-sulfonate (ANS). Addition of valinomycin to the synaptosomes was accompanied by an increase in the intensity of fluorescence of the probe at 464 nm (λexc = 365 nm), which is interpreted as reflecting hyperpolarization of(More)
Neuroleptics of the phenothiazine series and, in particular, trifluoperazine (TF), are widely used as specific antagonists of calmodulin (CM), for they block its various physiological effects in different cells, including in neurons and synaptic structures. It ha~ been shown [9, i0] that TF, by interacting with CM, inhibits Ca-dependent phosphorylation of(More)
Recent years have seen a steady increase in the evidence for an important role of cyclic nucleotides in platelet function [i]. Compounds leading to an increase in the intracellular cyclic AMP content have been shown to inhibit platelet aggregation [3, 4]. A fall in the cyclic AMP level in these cells has the opposite action. Meanwhile the importance of(More)
The applicability of the potential-sensitive dye diS-C3-(5) for the study of A23187 + Ca2+ induced plasma membrane hyperpolarization was tested in rat brain synaptosomes. An appropriate dye synaptosome ratio was chosen for the fluorescence titration dye in Ca-free Krebs-Ringer solution. The fluorescence intensity of the probe was increased upon the addition(More)
in the number of synapses took place on account of small synapses with 1-2 and 3-4 intersections with the control grid (Fig. id); the number of large synapses was a little reduced, The number of curved contacts increased. In this series of experiments, just as on the ist-4th day, synapses with asymmetrical composition predominated but there was an(More)