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PURPOSE To analyze the clinical and microbiological characteristics of microbial keratitis at the National Taiwan University Hospital in the preceding 10 years. DESIGN Retrospective cross-sectional study. METHODS Medical records were reviewed for all patients with clinically diagnosed microbial keratitis presenting at the National Taiwan University(More)
PURPOSE To determine the leading indications for penetrating keratoplasty and to identify changing trends in these indications during the past 12 years. METHODS We retrospectively performed a chart review of the hospital records of all patients undergoing penetrating keratoplasty at the National Taiwan University Hospital during a 12-year period(More)
PURPOSE To determine the surgical outcomes of therapeutic penetrating keratoplasty (PKP) and its role in the management of microbial keratitis. DESIGN Interventional case series. METHODS We retrospectively performed a chart review of the hospital records of all 151 patients undergoing therapeutic PKP for culture-proven microbial keratitis at the(More)
Goblet cell metaplasia and mucus overproduction contribute to the pathogenesis of chronic lung diseases, including asthma and chronic obstructive pulmonary disease (COPD). Notch signaling regulates cell fate decisions and is crucial in controlling goblet cell differentiation in the gut epithelium. Little is known, however, about how endogenous Notch(More)
BACKGROUND The biological mechanisms of how prenatal smoke exposure leading to atopic disorders remain to be addressed. Whether prenatal smoke exposure affects DNA methylation leading to atopic disorders is not clear. OBJECTIVE As most children suffering from atopic dermatitis (AD) continue to develop asthma later in life, we explored whether prenatal(More)
PURPOSE To evaluate the effects of tear film breakup on higher order aberrations of the anterior cornea in normal, dry, and post-LASIK eyes. METHODS In a prospective study, 120 eyes (120 subjects) comprised three groups: post-LASIK eyes, dry eyes, and normal eyes. Tear film break-up time (BUT) was measured by fluorescein dye under slit-lamp microscopy.(More)
PURPOSE To evaluate the effectiveness of conjunctival resection combined with Tenon layer excision in treating superior limbic keratoconjunctivitis (SLK) and the involvement of mast cells in SLK. DESIGN Retrospective, interventional case series. METHODS Forty eyes of 30 SLK patients who were unresponsive to medical treatment received superior bulbar(More)
PURPOSE To investigate the comorbidities of dry eye disease in a nationwide population-based data in Taiwan. METHODS This study features a study group and a comparison group. The study group comprised 12 007 patients who sought ambulatory care for treatment of dry eye in 2005 and 2006. In total, 36 021 randomly selected patients were in the comparison(More)
PURPOSE To analyze in vitro antibiotic susceptibility of bacterial isolates from patients with bacterial keratitis at the National Taiwan University Hospital over the past 12 years. DESIGN Retrospective cross-sectional study. METHODS Medical records were reviewed for patients with culture-proven bacterial keratitis at the National Taiwan University(More)
Our previous study has demonstrated cultivation of bovine corneal endothelial cells (BCECs) on the chitosan-polycaprolactone (PCL) blends. BCECs could grow well and express physiological phenotypes after PCL was introduced into chitosan by means of blending. The feasibility of using chitosan-PCL-blended membranes as scaffold and carrier for corneal(More)