I Iu Semenchenko

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Electron microscopy was used to study structural changes of synapses in sensorimotor, parietal, limbic cortical areas, hippocamp, blue spot and hypothalamus of old Wistar rats, aged 28-30 months. Polymorphism of ultrastructural changes in neuronal and synapse processes and individual variability of these shifts in the brain of old rats have been revealed.(More)
In the present study was determined the relative quantity subpopulations of lymphocytes, activated T-lymphocytes and CD95-antigen (Fas/APO-1) expression on lymphocytes in the peripheral blood of patients with diabetes mellitus type 2 (DM 2) and obesity in comparison with the healthy persons. The cells were analyzed by the method of flow cytometry using(More)
Diabetes mellitus (DM) is a main noninfectious disease, making significant influence on patients quality of life and life time. The medico-social role of diabetes is defined by wide prevalence of a disease in population and high risk of development of incapacitating complications. Therefore, considerable efforts of modern medicine focused on the study of(More)
AIM to investigate cytokine profile in patients with type 2 diabetes mellitus (DM) with different degree of obesity. 154 patients with type 2 DM were examined (55.2% women, 44.8% men). All patients received standard antihyperglycemic therapy; mean age was 46.1 +/- 0.82 years, mean duration of disease was 7.2 +/- 1.43 years. The patients were divided into(More)
The authors studied the neuronal ultrastructure of the sensorimotor cortex of rats exposed to 90 days of hypokinesia and at different times after its withdrawal. During prolonged restriction of motor activity, dystrophic changes seen in the cortical neurons were most demonstrable. During the first week of the posthypokinetic period, the degree of dystrophic(More)
Neuronal ultrastructure of the frontal and temporal cerebral cortex has been studied in persons 36-, 39-, 50-, 70-year-old, died from the ischemic heart disease and 73-, 83-year-old, whose deaths are not connected with vascular pathology. The neurons can be divided into several groups, depending on osmiophilic degree of their nucleus and cytoplasm:(More)
Dendrite ultrastructure was studied in different brain areas of old rats, aged 28-30 months. Different ultrastructural forms of the reactive and destructive processes in the dendrites, irregularity of their pathomorphological changes with ageing and greater destruction of large dendrites, as compared to small ones are demonstrated.
Using light and electron microscopy, the frontal, temporal and parietal cortical neurons were studied in 10 cases of senile dementia. It was found that along with general age-specific disorders of the ultrastructure of neurons and glial cells (varying degrees of chromatolysis, accumulation of lipofuscin, mitochondrial changes) the examination revealed(More)
UNLABELLED The aim of the study was to evaluate indexes of body composition in patients with obesity and diabetes mellitus type 2 during the application of a standard hypocaloric diet. MATERIAL AND METHODS in study were included 290 patients aged of 49 +/- 13 years. Patients were divided in two groups: 1) patients with obesity (n = 145), and 2) patients(More)
In semithin sections of the frontal and temporal cortex from the human brains the compensatory-adaptive changes of neurons and glia were studied. The specimens were obtained from 2 physiologically aged subjects, 7 cases of senile dementia, 2 cases of Alzheimer disease. Alongside with the destructive changes in nerve and glial cells, the(More)
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