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Background:Tamoxifen has anti-oestrogenic and anti-tumour activity in the breast, but is oestrogenic and carcinogenic in the endometrium. It can induce experimental tumours by both hormonal and DNA-damaging mechanisms, but its carcinogenic mode of action in human endometrium remains unclear.Methods:We investigated whether an epigenetic mechanism, involving(More)
Background:Endometrial cancer is the most common gynaecological malignancy in the United Kingdom. Diagnosis currently involves subjective expert interpretation of highly processed tissue, primarily using microscopy. Previous work has shown that infrared (IR) spectroscopy can be used to distinguish between benign and malignant cells in a variety of tissue(More)
The results in this series of fifty-seven patients confirms the safety and reliability of rapid atrial stimulation to terminate atrial flutter and atrial tachycardia. Transthoracic wires implanted at thoracotomy or transvenously placed atrial electrodes can be used for the confident intracardiac electrocardiographic diagnosis of tachyarrhythmias and for(More)
  • I I Patel, IIPriyesh P. Gandhi, IIINilesh D. Patel, IVJaimini Prajapati
  • 2014
I. Introduction In this high-speed generation and high-integration density systems, the synchronous adjustment between the different systems is very important. Asynchronous clock which were caused by the phase error would be a serious threat to the correctness of the operation of the whole circuit. The Phase Locked Loop (PLL) and Delay-Locked Loop (DLL) are(More)
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