I. I. Khabibrakhmanov

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In vitro and in vivo studies were performed to investigate the effects of M1-, M2-, M3-cholinoreceptors (M-AChR) blockade on the chronotropic and inotropic cardiac function in the rats of 1, 3, 6, 8 and 20 weeks old. These age groups were selected according to the development level of the autonomic regulation of the heart. It was found that the prior(More)
The study examined the effect of α1-adrenoceptor stimulation with methoxamine on chronotropic function of isolated heart perfused ex vivo according to Langendorff and cardiac chronotropy in vivo. Stimulation of α1-adrenoceptors in isolated heart induced gradually developing bradycardia, which progressed during several minutes. Similar stimulation in vivo(More)
By electron paramagnetic resonance method analyzed the production of nitric oxide (NO) in atrias and ventricles of the rat's heart, spinal cord and liver of rats after the contained in conditions of hypokinesia during 30, 60 and 90 days. It was discovered that the regime of hypokinesia leads to increase NO production in all the investigated tissues, and the(More)
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