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Using highly sensitive microarray-based procedures, we identified eight microRNAs (miRNAs) showing robust differential expression between 31 laser-capture-microdissected nasopharyngeal carcinomas (NPCs) and 10 normal healthy nasopharyngeal epithelial samples. In particular, miRNA mir-29c was expressed at one-fifth the levels in tumors as in normal(More)
BACKGROUND Nasopharyngeal carcinoma (NPC), which occurs at a disproportionately high rate among Chinese individuals, is associated with Epstein-Barr virus (EBV). Human leukocyte antigen (HLA) polymorphisms appear to play a role in NPC, because they are essential in the immune response to viruses. We used high-resolution HLA genotyping in a case-control(More)
To identify the molecular mechanisms by which EBV-associated epithelial cancers are maintained, we measured the expression of essentially all human genes and all latent EBV genes in a collection of 31 laser-captured, microdissected nasopharyngeal carcinoma (NPC) tissue samples and 10 normal nasopharyngeal tissues. Global gene expression profiles clearly(More)
Nitrosamine consumption and polymorphisms in CYP2E1, the product of which is involved in the activation of nitrosamines into reactive intermediates, have been shown to be associated with nasopharyngeal carcinoma (NPC) risk. Given that reactive intermediates created during nitrosamine metabolism are capable of DNA damage, we further hypothesized that(More)
Graduate Institute of Epidemiology, College of Public Health [Y-J. C., Y-C. C., J. Chu., J. Cha., Y. D. M., C-T. L., W-L. H., H. H.-H. H., H. H., J-F. C., C-J. C.], Graduate Institute of Microbiology [C-S. Y.], and Department of Otolaryngology [M-M. H.], College of Medicine, National Taiwan University, Taipei, 100 Taiwan; Department of Otolaryngology,(More)
OBJECTIVES To evaluate the prognostic value of maximum standardized uptake value (SUVmax) measured in [(18)F]-fluorodeoxyglucose positron emission tomography ((18)F-FDG PET) for patients with non-disseminated nasopharyngeal carcinoma (NPC). MATERIALS AND METHODS From January 2002 to July 2008, 371 NPC patients who underwent (18)F-FDG-PET before radical(More)
PURPOSE Radiotherapy is an integral part of the treatment modality for head-neck cancer (HNC), but in some cases the disease is radioresistant. We designed this study to identify molecules that may be involved in this resistance. METHODS AND MATERIALS Two radioresistant sublines were established by fractionated irradiation of the HNC cell lines, to(More)
Objectives: Nasopharyngeal carcinoma (NPC) is rare in most countries but occurs with relatively high frequency among southern Chinese populations throughout the world. A case-control study of NPC was conducted in Taiwan to investigate the importance of active and passive cigarette exposure and alcohol consumption as risk factors for this disease. Methods:(More)
INTRODUCTION Melanomas that arise in the nasal cavity or paranasal sinuses are rare and have a poor prognosis. In this study, we reviewed 15 patients in a tertiary referral centre and analyzed their treatment results and patterns of treatment failure. MATERIALS AND METHODS Fifteen patients diagnosed from January 1994 to February 2005 at the Chang Gung(More)
BACKGROUND There is no plasma marker for detecting oral cancer, one of the most frequent cancers worldwide. We developed a bead-based affinity-fractionated proteomic method to discover a novel plasma marker for oral cancer. METHODS Affinity purification of heparinized plasma with magnetic beads and matrix-assisted laser desorption/ionization(More)