I Heberlein

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In humans, selective attention is assumed to be under control of the frontal lobe. A significant proportion of patients with amyotrophic lateral sclerosis (ALS) shows impairments in various tasks touching frontal lobe function. We, therefore, undertook a study of event-related EEG potentials (ERPs) in eight non-demented ALS patients in order to investigate(More)
Stride parameters were established in 17 patients with idiopathic Parkinson's disease (PD; mean age 68.8 yrs.; Hoehn-Yahr stages 2 and 3) and in 33 healthy age-matched controls. Free-walking speed was lower in PD as were stride length and cadence. Impaired locomotor synergies in PD were reflected by a higher coefficient of variation of stride length; step(More)
OBJECTIVE To reevaluate concordance rates in 9 monozygotic (MZ) and 12 dizygotic (DZ) twin pairs with PD 8 years after the initial study. BACKGROUND Longitudinal investigations increase accuracy in clinical diagnosis of PD. METHODS Follow-up by personal interview and clinical examination. RESULTS Concordance rates were not different between MZ (3/9)(More)
OBJECTIVES It has been hypothesized that the dopaminergic deficit of older patients with Parkinson's disease (PD) is associated with a reduction in the dopamine-dependent personality trait "novelty seeking". It is unknown whether this may also be found in younger patients with PD whose dopaminergic deficit is considered to be purely motor. MATERIAL AND(More)
Present personality traits (Freiburg personality inventory, FPI-R), depression (von Zerssen's depression scale), and self assessed state of health were evaluated in 15 twin pairs (six monozygotic and nine dizygotic; mean age 62.5 years) discordant for idiopathic Parkinson's disease and in 17 unrelated healthy control subjects. The twins had additional(More)
We evaluated whether assessments of cognitive flexibility, memory, mood, somatic complaints, personality traits and finger tapping rate could be used to screen persons of at least 40 years of age for their possible genetic risk for idiopathic Parkinson's disease (PD). Thirty-five asymptomatic first-degree relatives (FPD) of PD families with at least two(More)
The etiology of Parkinson's disease (PD) is currently thought to be due to an interplay of genetic and environmental factors. We examined (1) familial prevalences of PD and essential tremor (ET) using a control population and personal investigation; (2) comorbidity and possible traits of a altered premorbid lifestyle in PD were also investigated. Sixty-six(More)