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The safety assessment of fragrance materials.
Safety evaluation of the large number of diverse chemicals used as fragrance ingredients follows a systematic prioritization of data generation and analysis, consideration of exposure and criticalExpand
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Apoptosis Induced in Rats by 4-Vinylcyclohexene Diepoxide Is Associated with Activation of the Caspase Cascades1
Abstract Previous studies have shown that ovotoxicity induced in rats by dosing with 4-vinylcyclohexene diepoxide (VCD) is likely via acceleration of the normal rate of atresia (apoptosis). TheExpand
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In vitro penetration and subchronic toxicity of alpha-methyl-1,3-benzodioxole-5-propionaldehyde.
alpha-Methyl-1,3-benzodioxole-5-propionaldehyde (methyl-3,4-methylene-dioxy-hydrocinnamic Aldehyde, MMDHCA) is a widely used commercially available fragrance material. Because of the wide range ofExpand
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The role of hepatocellular oxidative stress in Kupffer cell activation during 1,2-dichlorobenzene-induced hepatotoxicity.
1,2-dichlorobenzene (1,2-DCB), an industrial solvent, is a known hepatotoxicant. Two oxidative events in the liver contribute to 1,2-DCB-induced liver injury: an initial hepatocellular oxidativeExpand
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