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Peripheral blood lymphocytes (PBL) and CEM CD4+ T-cell line can be infected by herpes simplex virus-1 (HSV-1). CEM cells were characterized as a cellular model to study interactions occurring between HSV-1 and HIV-1. Virtually all cells were persistently infected by HSV-1 (CEM(HSV)) and expressed the latency associated transcripts, whereas only a fraction(More)
stage, perhaps as a primary event. Therefore, we should pay more attention to pathophysiological events related to the JAK2-negative clone in CMPD, including PV. In the ET patients, higher leukocyte and higher hemoglobin level were evident in JAK2-positive patients, indicating that CMPD with JAK2 constitutes a common proliferative characteristic. Kralovics(More)
BACKGROUND AND OBJECTIVES Retroviral vectors are widely used to deliver foreign genes to hematopoietic stem cells (HSC). Improvement of marking protocols needs reporter genes to allow rapid detection and efficient selection of transduced cells. The great potential of EGFP and LNGFR as reporter systems prompted us to compare them simultaneously, using the(More)
effects often wane as treatment time increases. The observation that vitamin D improves mood is consistent with several prior studies. For example, Jorde et al. reported that a low serum level of 25(OH)D among participants in the fifth Tromsø study in northern Norway was significantly associated with psychological depression. Lansdowne and Provost found(More)
The possibility of protecting human CD4+ lymphocytes from human immunodeficiency virus type 1 (HIV1) infection, through a suicide mechanism elicited by the HIV1 transcription apparatus itself, offers a potentially useful approach for gene therapy of the acquired immunodeficiency syndrome. A replication-defective lentiviral HIV1 vector (HYIRES-TK) was(More)
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