I. G. Vlasova

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The influence of semicarbazide (SC), an inhibitor of glutamate decarboxylase (GDC), on electrical and respiratory activity of the Purkinje cells and cortical neurons of mice was investigated in tissue culture. A biphase character of the SC influence on the investigated parameters was demonstrated. The first excitatory phase could be produced by the blocking(More)
Seasonal and circadian rhythms of neuronal and organism resistance to convulsive effect of strychnine and penicillin were studied in vivo on mice and rats and in vitro on cultured mouse cerebellar sections. Resistance was assessed by the latency of seizures in mice and neuronal response to convulsants in sections. In the night and morning time (0:00-9:00)(More)
platelets. This synchronization may be mediated by fibrinogen molecules, which bind to the specific receptors (GPIIb /GPII Ia ) , forming a kind of loose network. Here the second type of secretion and irreversible platelet aggregation do not take place [1]. Ca 2+ ions are required for the formation of receptor heterodimer and its binding to fibrinogen [8].(More)
Spontaneous electrical activity, adenyl nucleotides' and cytochromes' contents, activity of respiratory chain enzymes complex in brain slices, homogenate and isolated mitochondria of rats, preliminary divided into non-resistant (NR) and high resistant (HR) animals by their sensitivity to hypobaric hypoxia have been investigated. It has been shown that in HR(More)
Using survival slices of the rat cerebellum, we studied the influence of opiates (alpha- and beta-endorphines, met-enkephalines) as well as substance P (SP) on the impulse activity (IA) of neurons. Low doses of the studied substances (10(-8)-10(-10) M) for the most part increased the IA of the neurons, while high doses (10(6)-10(-5) M) produced biphasic(More)
Fibrillar degeneration after extirpation of the frontal cortical field F2, central part, was observed in dogs by Nauta--Gygax and Fink--Heimer's methods. Degenerated fibrillae were stated to form two bundles and terminate near the neurons of nonspecific thalamic nuclei: n. ret, MD, pf, sprf, as well as in the neurons of specific thalamic nuclei: n. Vna,(More)
The correlation between the pattern of a neuron's reaction to acute hypoxia and individual resistance to oxygen deficit is studied on ratsin vivo as well as on surviving slices of their cerebellumin vitro. According to the survival time in a pressure chamber simulating an altitude of 11 km all the rats were divided into groups of high resistance, medium(More)
A comparative investigation of morphological, electrophisiological and metabolic indices of the functioning of cerebellar neurons developing in vivo and in conditions of the organotypical culture permitted us to distinguish a period (20--25 days) when properties of the culture of nervous tissue most resemble the characteristics of the brain of adult(More)