I. G. Rebrov

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We have studied muscimol-induced 36Cl− conductivity in synaptoneurosomes prepared from the frontal and somatosensory cortex of rats with three types of epileptic activity: tonic-clonic pentylenetetrazole kindling in Wistar rats, nonconvulsive absence pentylenetetrazole kindling in Wistar rats, and a genetic model of epilepsy in WAG/Rij rats. We used two(More)
Experiments on Wistar rats showed a decrease in basal and muscimol-stimulated 36Cl− entry into synaptoneurosomes isolated from the cerebral cortex during the middle stage of kindling (30 mg/kg pentylenetetrazole intraperitoneally for 14 days) characterized by the development of convulsions of higher (2 points) severity in comparison with the previous stage.
Experiments on Wistar rats showed that basal and muscimol-induced 36Cl− entry into synaptoneurosomes isolated from the brain cortex decreased after kindling (30 mg/kg pentylenetetrazole intraperitoneally for 30 days) in animals with seizure severity score 4–5. Changes in Cl− conduction during kindling are discussed.
Functional activity of the CGABA(A)-receptor/Cl(-) ionophore complex was investigated the muscimol-stimulated entry of the radioactive isotope 36Cl(-) in synaptoneurosomes in changing the structure and permeability of neuronal membranes. Integrity of the membranes was damaged by removal of Ca(+2) and Mg(+2) from the incubation medium and by the method of(More)
Early in ontogeny, various parts of the nervous system, including the hippocampus of newborn rats, generate a special rhythmic activity, giant depolarizing potentials [1]. The latter are supposed to play an important role in the body growth and connection formation [2]. Giant potentials are accompanied by synchronous excitation of a large group of cells(More)
Effects of corazol (pentylenetetrazole, PTZ) on the GABAA receptor-channel complex mediated 36Cl- influx into synaptoneurosomes isolated from rat cerebral cortex, were studied. PTZ inhibited the 36Cl- influx stimulated by a GABA agonist, muscimol, concentration-dependently with an IC50 of 2.11 +/- 0.25 mM. In addition, the rate of muscimol-dependent(More)
Effects of picrotoxin and bicuculline on the muscimol-dependent36Cl− entry into synaptoneurosomes of the rat cerebral cortex are examined as well as desensitization of36Cl− entry at muscimol concentrations of 5 and 50 μM. At the 5 μM concentration (which is close to the muscimol IC50), picrotoxin and bicuculline inhibited Cl− entry into synaptoneurosomes(More)
Muscimol-stimulated Cl- conductance in brain cortex synaptoneurosomes from Wistar rats decreased 15 min after single intraperitoneal injection of pentylenetetrazole in a subconvulsive dose. These changes reflected a decrease in functional activity of the GABAA-receptor/Cl- ionophore complex. Muscimol-stimulated Cl- conductance in synaptoneurosomes returned(More)
Muscimol-stimulated Cl− conductance of synaptoneurosomes from the cerebral cortex of Wistar rats increased during the early stage of pharmacological kindling not inducing the seizure response in animals. Picrotoxin, bicuculline, and pentylenetetrazole potentiated inhibition of muscimol-dependent 36Cl− entry into synaptoneurosomes, which attested to(More)
A study is performed of the effect of the convulsants picrotoxin and bicuculline, blockers of GABA-dependent Cl−-conductivity, on the rate of desensitization of muscimol-induced36Cl− entry into synaptoneurosomes isolated from rat cortex. Both picrotoxin and bicuculline, despite the difference in the mechanisms of inhibition of the GABA receptor/Cl−(More)