I G Fulga

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The role of endogenous enkephalins in behavioural control in mice was investigated by i.v. injection of RB 101 (N-[(R,S)-2-benzyl-3[(S)(2-amino-4- methylthio)butyl dithio]-1-oxopropyl]-L-phenylalanine benzyl ester). RB 101 is a recently reported systemically active mixed inhibitor prodrug of the two enzymes which metabolize the enkephalins neutral(More)
The anxiolytic effect of the calcium channel blockers nifedipine and verapamil was tested in mice using two test: the conditioned suppression of the motility test and the black and white box test. The nifedipine but not the verapamil, in low doses (0.1 mg/kg b.w), proved anxiolytic effect and both nifedipine and verapamil in high dose (1.6-2.5 mg/kg b.w)(More)
The effects of the selective adenosine A1 receptor agonist N6-cyclopentyladenosine (CPA; 1 and 0.1 mg/kg, i.p.) and the A1 selective antagonist 8-cyclopentyl-1,3-dipropylxanthine (CPX) have been examined on the electroencephalogram (EEG) of intact rats. From four EEG leads the EEG signal was subjected to Fast Fourier Transform and analysed both in narrow(More)
The effect of kanamycin and gentamicin on frog n.sciatic-m.gastrocnemian preparatus was analyzed. Both substances decreased the muscular contraction in both after direct electrical stimulation of the muscle and electrical nerve stimulation, in a dose-dependent manner. Both substances were used at a concentration near the therapeutical concentration in(More)
Effect of calcium channel blocker nifedipine on the electrical activity of the brain in anaesthetized rats was studied. The electoencephalographic signals were registered on a computer as series of data and thereafter they were decomposed by Fourier analysis in very narrow fields of frequency. The electrical activity of the brain of the control rats was(More)
By means of a conveyer belt two types of conditioned reflexes were developed in rats, at two functional levels. When these had become stable, we observed the animals' behaviour during a morphine treatment, until they developed tolerance. Thereafter the treatment with morphine was suddenly discontinued, or morphine was replaced by pentazocine or reserpine.(More)
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