I. G. Dubinina

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The ratio between the de novo and “reserve” pathways of synthesis of pyrimidine nucleotides of RNA changes in the de novo direction in the spleen, thymus, and liver of mice and rats with fast growing transplantable hepatomas. This phenomenon is due to a sharp decrease in uridine utilization by the tissues of the tumor-bearing animal, for the tumor utilizes(More)
Uridine kinase (ATP: uridine-5-phosphotransferase, EC was isolated from cytosol of rat Zajdela ascite hepatoma cells by fractionation with ammonium sulfate and gel-filtration on Sephadex G-200. The enzyme has a pH optimum of 7.2 - 7.8; Km for uridine is 4.8 . 10(-5) M, that for ATP - 1.9 . 10(-4) M. The optimal ratio of ATP of Mg2+ is 2.6. The(More)
Fullerenols are nanosized water-soluble polyhydroxylated derivatives of fullerenes, specific allotropic form of carbon, bioactive compounds and perspective pharmaceutical agents. Antioxidant activity of fullerenols was studied in model solutions of organic and inorganic toxicants of oxidative type - 1,4-benzoquinone and potassium ferricyanide. Two(More)
In the spleen, thymus and liver of mice and rats carrying transplantable rapidly growing hepatomas a shift between the de novo and "salvage" pathways of the pyrimidine RNA nucleotides synthesis in favour of the de novo one was observed. The phenomenon was found to be the manifestation of a drastically diminished uridine utilization by the host tissues, this(More)
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