Learn More
Phthalocyanines, porphyrin-like compounds with maximum absorption in the red, which were previously reported to localize selectively in tumours, have been shown to be efficient photosensitizers of mammalian cells in culture, thus making them possible candidates to replace haematoporphyrin derivatives in cancer phototherapy.
The diamine oxidase catalysed deamination of putrescine was reducedin vitro by histamine at concentrations occurring in the gut. An oral application of histamine, however, had no effect on the enzymic activity. When the histamine was injected i.p. a decrease of intestinal diamine oxidase activity was observed which, however, did not depend on histamine but(More)
Phthalocyanines are photosensitizers evaluated for use in photodynamic therapy of cancer. As such, the dependence of the bioresponse on the light fluence rate may be of clinical importance. The effect of the fluence rate of white light from 0.165 to 3.3 kJ m-2 min-1 was studied in Chinese hamster cells and human lymphocytes, using as endpoints(More)
The effect of the central metal atom on the photodynamic activity of phthalocyanine dyes has been estimated by cytotoxicity to cultured Chinese hamster cells. Chloroaluminium phthalocyanine,, followed by the Zn- derivate, were found to be the only active dyes. In parallel it was found that visible light (615 +/- 10 nm) excitation of phthalocyanines(More)
The riboflavin-sensitized photooxidation of ascorbate ion (HA-) to ascorbate radical (A.-) was followed by electron spin resonance (ESR) spectroscopy in conjunction with oxygen depletion measurements. In air-saturated aqueous media, steady-state amounts of A.- are rapidly established upon irradiation. The ESR signal disappears within a few seconds after the(More)