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This study was undertaken to assay the effect of lovastatin on the glycogen synthase kinase-3 beta (GSK-3β) and collapsin responsive mediator protein-2 (CRMP-2) signaling pathway and mossy fiber sprouting (MFS) in epileptic rats. MFS in the dentate gyrus (DG) is an important feature of temporal lobe epilepsy (TLE) and is highly related to the severity and(More)
Antibody-dependent enhancement (ADE) of virus infections can be induced by subneutralizing concentrations of specific antibodies. We recently demonstrated ADE in human monocytes infected with enterovirus 71 (EV71). The current study was designed to extend these observations by determining the effect of ADE on the pathogenesis of EV71 infection in newborn(More)
BACKGROUND Brainstem encephalitis (BE) and pulmonary edema (PE) are notable complications of enterovirus 71 (EV71) infection. OBJECTIVE This study investigated the immunoregulatory characterizations of EV71 neurological complications by disease severity and milrinone treatment. STUDY DESIGN Patients <18 years with virologically confirmed EV71 infections(More)
BACKGROUND The conserved Notch signaling pathway regulates cell fate decisions and maintains stem cells in multicellular organisms. Up-regulation of Notch signaling is observed in several types of cancer and is causally involved in proliferation and survival of cancer cells. Thus, it is of great interest to look for anti-Notch reagents for therapeutic(More)
BACKGROUND Long-term care residents are susceptible to constipation and one-half to three quarter of older nursing home residents receive laxatives regularly. OBJECTIVES The purpose of this study was to evaluate the factors related to abnormal bowel function and explore the effectiveness of laxative treatment among the elderly residents of a nursing home.(More)
BACKGROUND Developmental delay (DD) in infants and children is one of the chief complaints of parents. It has been established that the concerns of parents are as accurate as quality screening tests. Some kinds of concerns are particularly useful in the early detection of associated developmental problems. The purpose of this study was to investigate the(More)
BACKGROUND A rapid surge of female breast cancer has been observed in young women in several East Asian countries. The BIM deletion polymorphism, which confers cell resistance to apoptosis, was recently found exclusively in East Asian people with prevalence rate of 12%. We aimed to evaluate the possible role of this genetic alteration in carcinogenesis of(More)
BACKGROUND This hospital-based study explored how effectively parents discern their children's cognitive deficits at a preschool age since few studies have addressed preschool children's cognitive problems. METHODS One hundred and forty-six preschool children suspected of possessing a cognitive deficit were recruited and subjected to further cognitive(More)
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