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Enterovirus (EV) is an RNA virus that has circulated with different serotypes and genotypes worldwide. Enterovirus 71 (EV71) is a major neurotropic virus that causes severe brain stem encephalitis (BE) in infants and young children. The most vulnerable age for fatal infection is 6 to 11 months. This is associated with the coincident decline in maternal(More)
This study was undertaken to assay the effect of lovastatin on the glycogen synthase kinase-3 beta (GSK-3β) and collapsin responsive mediator protein-2 (CRMP-2) signaling pathway and mossy fiber sprouting (MFS) in epileptic rats. MFS in the dentate gyrus (DG) is an important feature of temporal lobe epilepsy (TLE) and is highly related to the severity and(More)
Proteus mirabilis, a human pathogen that frequently causes urinary tract infections, is intrinsically highly resistant to cationic antimicrobial peptides, such as polymyxin B (PB). To explore the mechanisms underlying P. mirabilis resistance to PB, a mutant which displayed increased (> 160-fold) sensitivity to PB was identified by transposon mutagenesis.(More)
BACKGROUND The purpose of this study was to evaluate the delayed effects of balance training program on hemiplegic stroke patients. METHODS A total of 41 ambulatory hemiplegic stroke patients were recruited into this study and randomly assigned into two groups, the control group and trained group. Visual feedback balance training with the SMART Balance(More)
BACKGROUND Children with developmental delay (DD) have a variety of problems in developmental functions. The purposes of this study were to analyze the underlying diseases and risk factors in children with different functional delays. METHODS We collected data on 1048 children who underwent assessments of developmental function, related diseases, and risk(More)
Concerns over health risks and financial costs have caused difficulties in the management of arsenic contaminated land in Taiwan. Inflexible risk criteria and lack of economic support often result in failure of a brownfields regeneration project. To address the issue of flexible risk criteria, this study is aimed to develop maps with receptor-specific risk(More)
Antibody-dependent enhancement (ADE) of virus infections can be induced by subneutralizing concentrations of specific antibodies. We recently demonstrated ADE in human monocytes infected with enterovirus 71 (EV71). The current study was designed to extend these observations by determining the effect of ADE on the pathogenesis of EV71 infection in newborn(More)
PURPOSE To evaluate the preventive effects of topical skin disinfection with chlorhexidine on bloodstream infection (BSI) associated with totally implantable venous port (Port-A). METHODS Two consecutive cohorts of solid cancer patients were prospectively followed for the occurrence of Port-A associated BSI (PABSI). The first cohort used povidone-iodine(More)
AIMS To examine the prevalence rate and predictors of alcohol use problems among patients undergoing methadone maintenance treatment (MMT). DESIGN This was a prospective follow-up study. PARTICIPANTS Study population included 438 patients who underwent more than 6 months of MMT. MEASUREMENTS Demographic and clinical characteristics were collected for(More)