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1. Intracellular calcium concentration ([Ca2+]i) was measured in single myocytes isolated from either the cardiac ventricle or the mesenteric artery of the rat. 2. In both cardiac and smooth muscle, the application of caffeine produced an increase of [Ca2+]i which spontaneously decayed back to resting levels. In vascular smooth muscle cells, removal of(More)
1. The intracellular Ca2+ concentration ([Ca2+]i) was measured in mesenteric artery smooth muscle cells using the fluorescent indicator indo-1. 2. Noradrenaline (1-10 microM) produced a transient increase in [Ca2+]i. This response was unaffected by the removal of external calcium suggesting that the bulk of the increase in [Ca2+]i produced by noradrenaline(More)
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