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Some characteristics of the myelin basic protein from dog spinal cord were studied. The basic protein has a molecular weight of 18,000; the isoelectric point is 9.5. The amino acid composition of the protein was determined. Electrophoresis in 15% polyacrylamide gel revealed the heterogeneity of the basic protein. The EAE-activity of the basic protein was… (More)
Activity of cathepsin D in synovial fluid of the knee joint and blood of 113 patients with injuries of this joint was studied. A conclusion is made about pathogenetic role of cathepsin D in the development of reactive arthritis.
The intracysternal administration of the immunoglobulins G fraction containing mainly antiboides to myelin basic protein activites acid protease in the lysosomic, soluble fractions and in myelin of the brain white matter and spinal cord of dogs. Administration of the fraction of immunoglobulins G obtained from the intact dog blood serum does not change… (More)
Distinct activation of rat brain acid proteinase was found, if blood serum from patients with some neuropsychical diseases or blood serum from the animals immunized by the patient brain tissue as well as by main protein of myelin were added into the incubation mixture; this demonstrates the labilizing effect of antibrain antibodies on lysosomes. The… (More)