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Local accumulation of cells (hypercellularity) in the intima of the arterial wall as a result of cell proliferation is recognized as one of the major manifestations of human atherosclerosis. In the present study we have used a monoclonal antibody against PCNA to identify the proliferative activity, in uninvolved intima of human aorta classified as diffuse(More)
To evaluate the role of lipid oxidation in atherogenesis the levels of lipid- and protein-bound products of peroxidation in normal and atherosclerotic areas of human aorta were investigated. The level of fluorescent (360/430 nm) lipid products was measured in chloroform-methanol extracts of aortic tissue. Normal intima, initial lesions and fatty streaks had(More)
Inflammatory reactions driven by an accumulation in the intima of immune-inflammatory cells and focal lipid depositions are the hallmarks of atherogenesis. It is commonly accepted that immune-inflammatory cell accumulation and lipid deposition are associated with the very earlier stage of atherosclerosis but no study has yet focused on the determination of(More)
The functional activity of platelets was examined in patients with coronary heart disease and healthy individuals during cold test (CT). Patients prone to vasospastic responses to CT exhibited platelet activation along with beta-thromboglobulin release and formation of spontaneous platelet aggregates. Comparison of functional changes in platelet functional(More)
The activity of hexokinase, dehydrogenases of pentose cycle, total lactate dehydrogenase, and cytochrome-C-oxidase level was determined in the aorta of rats with hyperthyroidism caused by the intraperitoneal administration of L-thyroxin. In the administration of hormone doses approaching the physiological ones there was an increase in the activity of(More)
The growth rate constant of platelet thrombi as a function of mean blood flow velocity was studied using mesentery vessels of the white rat. An advanced mathematical model for the kinetics of platelet thrombi was developed. The dependence of platelet activation delay time upon the distance from the damaged vessel wall is pointed out as a result of(More)
In isolated papillary muscles, a 5-minute irradiation with the He-Ne-laser Shuttle-1 enhances the maximal strength of isometric contraction and acceleration of relaxation. In physiological mode of mechanical loads, the irradiation with the laser red light enhances the myocardium contractability at all final systolic lengths with simultaneous enhancement of(More)