Lipid peroxidation processes were studied in the striatum during stress in conditions of prior administration of cortisol. Three doses of cortisol (25 mg/kg, daily) had no significant effect on the levels of lipid peroxidation products six days after injections ended. However, lipid peroxidation responses to stress during this period in animals given… (More)
The processes of free-radical oxidation of proteins and lipids and superoxide dismutase activity were studied in neurons and neuroglia of the cerebral cortex in rats during ontogenesis and after prenatal stress. Regardless of age, normal animals were found to have higher levels of free-radical lipid and protein oxidation in neurons than in glia. This same… (More)
Processes of free radical oxidation of protein, lipids, and activity of superoxiddismutase in neurons and glial cells of the rat brain cortex in ontogenesis and after prenatal stress. Irrespective of age, the level of free radical oxidation of lipids and proteins in neurons is higher in comparison with the glia. The same was found in the study of… (More)
The amount of lipid peroxidation products (conjugated dienes and trienes and Schiff bases) in cortical neurons of the cerebral hemispheres decreased by 30% at the peak of convulsions observed 10-15 min after intraperitoneal injection of picrotoxin. In neuroglial cells of control animals the intensity of lipid peroxidation in was 1.7-2.0 times lower.… (More)
The responses of cats with different levels of taste sensitivity to phenylthiocarbamide (PTC) bitters to five-minute hypoxia were studied; PTC sensitivity is a genetic marker of the activity of the cAMP system. Animals able to perceive PTC showed a number of functional differences, with higher levels of resistance to anoxia, than those which could not… (More)
High-frequency stimulation eliciting long-term post-tetanic potentiation of neuronal excitation in slices of the rat olfactory cortex was accompanied by changes in the metabolism of phospholipid components of cell membranes. At the first stage of the development of long-term potentiation (10 min after tetanization), there was a reduction in phosphoinositide… (More)
Responses to a 5-min anoxia were studied in cats with different taste sensitivity for phenilthiocarbamide (PTC). The sensitive animals were more resistant against hypoxia. The difference in the cats seems to be determined by the condition of the cAMP system involved in adaptive responses.
A long-term potentiation of the rat olfactory cortex slices induced by a high-frequency stimulation is followed by membrane phospholipid changes. Activation of the phosphoinositide metabolism and normalising of phosphatidylethanolamine methylation occurs within 60 min after tetanisation when the potentiation fades. The findings reveal a regulating role of… (More)
It was demonstrated that a decrease in the intensity of methylation of phosphatidylethanolamine in sections of rat olfactory cortex is observed 15 min following the introduction of picrotoxin (10(-5) M) into the incubation medium. The decrease in the intensity of methylation of phospholipids may be closely linked to the opening of ion channels, since it is… (More)
Within 15 min after addition of picrotoxin to incubation medium, a reduction of the phosphatidylethanolamine methylation occurred. The reduction seems to be related to opening of ion channels since during this period of the picrotoxin action the maximal membrane depolarisation takes place.