I. A. Beslaneev

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After more than centenary successful use of nitroglycerin in clinical practice, scientists revealed that its medicinal effect is based on release of potent vasodilator nitric oxide (NO). Moreover, the experiments showed that NO plays an important role in hypoxia vasodilator mechanisms. Since nitroglycerin is an exogenous NO donor and moderate hypoxia(More)
AIM To study characteristics of hemodynamics, spectral analysis of heart rate variability (HRV) and their association with the total blood concentration of stable metabolites of nitric oxide (nitrites and nitrates) in patients with hypertension living in highlands. PATIENTS AND METHODS 110 natives of the highlands of Elbrus region were examined. All of(More)
Hemodynamics, geometry of the left myocardium ventricle (LV), blood nitrogen oxide and their interdependence were studied in hypertensive (n = 90) and normal mountain dwellers (n = 40) at the age of 37 to 72 years. The patients underwent general clinical and outpatient examination, electro- and echocardiography. The hypertensive patients were diagnosed for(More)
Heart rate variability (HRV), hemodynamics, cerebral α rhythm, and systemic relations between them have been investigated in 35 normal human subjects at the age of 37.2 ± 3.8 years. The results of comprehensive clinical, functional and instrumental HRV investigation, electroencephalography (EEG) using 21 monopolar electrodes, and blood pressure (BP)(More)
AIM To estimate concentrations of stable metabolites of nitric oxide (NO)--nitrites and nitrates--in blood components of hypertensive patients living in high mountains. MATERIAL AND METHODS The study included 90 healthy subjects and 90 patients with hypertension of different severity and duration living in high mountain regions near Elbrus. The age of the(More)
AIM To reveal the specific features of cardiac hemodynamics and endothelial function in high-altitude native dwellers with arterial hypertension (AH). MATERIALS AND METHODS 90 native dwellers from high-altitude and plain areas, who had Stages I and II AH, were examined. To assess cardiac contractility, central and peripheral hemodynamics, the authors used(More)
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