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In vivo knowledge of the spatial distribution of viable, necrotic, and hypoxic areas can provide prognostic information about the risk of developing metastases and regional radiation sensitivity and may be used potentially for localized dose escalation in radiation treatment. In this study, multimodality in vivo magnetic resonance imaging (MRI) and positron(More)
We have measured the decay of NMR multiple quantum coherence intensities both under the internal dipolar Hamiltonian as well as when this interaction is effectively averaged to zero, in the cubic calcium fluoride ͑CaF 2 ͒ spin system and the pseudo-one-dimensional system of fluoroapatite. In calcium fluoride the decay rates depend both on the number of(More)
Insufficient vascular reserve after an ischemic stroke may induce biochemical cascades that subsequently deteriorate the blood-brain barrier (BBB) function. However, the direct relationship between poor cerebral blood volume (CBV) restoration and BBB disruption has not been examined in acute stroke. To quantify BBB integrity at acute stages of transient(More)
This study presents the first demonstration of the MR signal decay due to diffusion in the internal field (DDIF) for in vivo knee trabecular bone imaging. DDIF contrast was compared with high resolution FLASH, T 1 , and T 2 * mapping in healthy volunteers. DDIF maps showed spatial variation, superimposed on a T 1 background, reflecting trabecular structure.(More)
Solid state Nuclear Magnetic Resonance (NMR) allows us to explore a large coherent spin system and provides an ideal test-bed for studying strongly interacting multiple-spin system in a large Hilbert space. In this thesis, we experimentally investigate the spin dynamics in a rigid lattice of dipolarly coupled nuclear spins using multiple quantum NMR(More)
The authors regret that there are typos in the section " Dynamic Contrast-Enhanced MRI. " For the T 1-weighted DCE-MRI, a fast low-angle shot (FLASH) sequence was used with a 41.77 ms TR and 5 slices (not 33 ms TR and 4 slices as stated originally), resulting in a temporal resolution of 5.347 seconds. These were pure typographical errors and do not affect(More)
In comparison to the well-documented significance of intravascular deoxyhemoglobin (deoxyHgb), the effects of dissolved oxygen on the blood-oxygen-level-dependent (BOLD) signal have not been widely reported. Based on the fact that the prolonged inspiration of high oxygen fraction gas can result in up to a sixfold increase of the baseline tissue oxygenation,(More)
With the applications of magnetic resonance imaging (MRI) at higher magnetic fields increasing, there is demand for MRI contrast agents with improved relaxivity at higher magnetic fields. Macromolecule-based contrast agents, such as protein-based ones, are known to yield significantly higher r1 relaxivity at low fields, but tend to lose this merit when used(More)