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Involvement of G-Protein-Coupled Receptor 40 in the Inhibitory Effects of Docosahexaenoic Acid on SREBP1-Mediated Lipogenic Enzyme Expression in Primary Hepatocytes
TLDR
DHA downregulates the expression SREBP-1-mediated lipogenic enzymes via GPR40 in primary hepatocytes, and downregulated lipogenesis enzyme expression in GPR120-null hepatocytes.
Auranofin prevents liver fibrosis by system Xc-mediated inhibition of NLRP3 inflammasome
TLDR
It is demonstrated that auranofin-induced inhibition of the NLRP3 inflammasome in bone marrow-derived macrophages and kupffer cells was mediated via inhibition ofThe cystine-glutamate antiporter, system Xc, which advances the understanding of the mechanism by which auran ofin exerts its therapeutic effects.
Discovery and Structure-Activity Relationships of Novel Template, Truncated 1'-Homologated Adenosine Derivatives as Pure Dual PPARγ/δ Modulators.
TLDR
PPARγ/δ dual modulators functioning as both PPARγ partial agonists and PPARδ antagonists promoted adiponectin production, suggesting their therapeutic potential against hypoadiponectinemia-associated cancer and metabolic diseases.
Auranofin Inhibits RANKL-Induced Osteoclastogenesis by Suppressing Inhibitors of κB Kinase and Inflammasome-Mediated Interleukin-1β Secretion
TLDR
Data strongly support the use of auranofin for the prevention of osteoclast-related osteoporosis.
Disease-specific eQTL screening reveals an anti-fibrotic effect of AGXT2 in nonalcoholic fatty liver disease
TLDR
A disease-specific expression quantitative trait loci (eQTL) screen to identify novel genetic factors that specifically act on NAFLD progression on the basis of genotype found that AGXT2-rs2291702 protects against liver fibrosis in a genotype-dependent manner with the potential for therapeutic interventions.
CD44 is involved in liver regeneration through enhanced uptake of extracellular cystine
Dear Editor, Liver regeneration triggered by fulminant liver damage accompanies the proliferation of hepatic progenitor cells (HPCs). Thus, there has been considerable interest in identifying
SNX10-mediated degradation of LAMP2A by NSAIDs inhibits chaperone-mediated autophagy and induces hepatic lipid accumulation
TLDR
It is demonstrated that NSAIDs induced SNX10- and CTSA-dependent degradation of LAMP2A, thereby leading to the suppression of CMA, thus leading to NSAID-induced steatosis and hepatotoxicity.