Skip to search formSkip to main contentSkip to account menu

Downregulation of PHGDH expression and hepatic serine level contribute to the development of fatty liver disease.

View on PubMed (opens in a new tab)

Involvement of G-Protein-Coupled Receptor 40 in the Inhibitory Effects of Docosahexaenoic Acid on SREBP1-Mediated Lipogenic Enzyme Expression in Primary Hepatocytes

DHA downregulates the expression SREBP-1-mediated lipogenic enzymes via GPR40 in primary hepatocytes, and downregulated lipogenesis enzyme expression in GPR120-null hepatocytes.
View PDF (opens in a new tab)

Auranofin Inhibits RANKL-Induced Osteoclastogenesis by Suppressing Inhibitors of κB Kinase and Inflammasome-Mediated Interleukin-1β Secretion

Data strongly support the use of auranofin for the prevention of osteoclast-related osteoporosis.
View PDF (opens in a new tab)

CD44 is involved in liver regeneration through enhanced uptake of extracellular cystine

The mechanistic roles of CD44, a cell surface marker for hepatic regeneration,1 in HPC proliferation and redox homeostasis are identified and verified.
View on PubMed (opens in a new tab)

Auranofin prevents liver fibrosis by system Xc-mediated inhibition of NLRP3 inflammasome

It is demonstrated that auranofin-induced inhibition of the NLRP3 inflammasome in bone marrow-derived macrophages and kupffer cells was mediated via inhibition ofThe cystine-glutamate antiporter, system Xc, which advances the understanding of the mechanism by which auran ofin exerts its therapeutic effects.
View on Springer (opens in a new tab)

Discovery and Structure-Activity Relationships of Novel Template, Truncated 1'-Homologated Adenosine Derivatives as Pure Dual PPARγ/δ Modulators.

PPARγ/δ dual modulators functioning as both PPARγ partial agonists and PPARδ antagonists promoted adiponectin production, suggesting their therapeutic potential against hypoadiponectinemia-associated cancer and metabolic diseases.
View on PubMed (opens in a new tab)

SNX10-mediated degradation of LAMP2A by NSAIDs inhibits chaperone-mediated autophagy and induces hepatic lipid accumulation

It is demonstrated that NSAIDs induced SNX10- and CTSA-dependent degradation of LAMP2A, thereby leading to the suppression of CMA, thus leading to NSAID-induced steatosis and hepatotoxicity.
View PDF (opens in a new tab)

Disease-specific eQTL screening reveals an anti-fibrotic effect of AGXT2 in non-alcoholic fatty liver disease.

View on PubMed (opens in a new tab)

Disease-specific eQTL screening reveals an anti-fibrotic effect of AGXT2 in nonalcoholic fatty liver disease

A disease-specific expression quantitative trait loci (eQTL) screen to identify novel genetic factors that specifically act on NAFLD progression on the basis of genotype found that AGXT2-rs2291702 protects against liver fibrosis in a genotype-dependent manner with the potential for therapeutic interventions.
View via Publisher (opens in a new tab)

Circulating small extracellular vesicles promote proliferation and migration of vascular smooth muscle cells via AXL and MerTK activation

An essential role is proposed for csEVs in proliferation and migration of VSMCs and the feasibility of dual AXL/MerTK inhibitors in the treatment of vascular diseases is highlighted.
View on Springer (opens in a new tab)
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)