Hyun Shik Lee

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When Y-1 mouse adrenal tumor cells were treated with sodium orthovanadate, an agent disrupting BHK21-F cell microtubule-intermediate filament (IF) interactions, there was no change in the amount of 20-dihydroprogesterone produced. A neurofilament-microtubule perturbing agent, beta,beta-iminodipropionitrile (IDPN), enhanced the ability of Y-l cells to(More)
Calcineurin (CN) is a calcium- and calmodulin-dependent serine/threonine phosphatase. In immune cells, CN controls the activity of a wide range of transcription factors, including nuclear factor of activated T, nuclear factor-kappa B, c-fos, and Elk-1. CN plays an important role in synoviocyte activation and arthritis progression in vivo and this function(More)
BACKGROUND Leucine-rich alpha 2 glycoprotein (LRG) has been identified as a serum protein elevated in patients with active rheumatoid arthritis (RA). Although the function of LRG is ill-defined, LRG binds with transforming growth factor (TGF)-β and enhances Smad2 phosphorylation. Considering that the imbalance between T helper 17 (Th17) cells and regulatory(More)
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