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Anti-inflammatory plant flavonoids and cellular action mechanisms.
TLDR
The effect of flavonoids on eicosanoid and nitric oxide generating enzymes and the effect on expression of proinflammatory genes are summarized and a potential for new anti-inflammatory agents are discussed.
Effects of sophoraflavanone g, a prenylated flavonoid from sophoraFlavescens, on cyclooxygenase-2 andIn Vivo inflammatory response
TLDR
Although the potencies of inhibition were far less than that of a reference drug, prednisolone, this compound showed higher antiinflammatory activity when applied topically, suggesting a potential use for several eicosanoidrelated skin inflammation such as atopic dermatitis.
Anti-inflammatory activity of pectolinarigenin and pectolinarin isolated from Cirsium chanroenicum.
TLDR
Results suggest that pectolinarigenin and pectolinarin possess anti-inflammatory activity and that they may inhibit eicosanoid formation in inflammatory lesions, and certainly contribute to the anti- inflammatory mechanism of C. chanroenicum.
Biochemical pharmacology of biflavonoids: Implications for anti-inflammatory action
TLDR
This work has shown that certain biflavonoids exhibit anti-inflammatory activity through the regulation of proinflammatory gene expression in vitro and in vivo and that these molecules also exhibit cyclooxygenase-2 inhibitory activity.
Inhibition of collagenase by naturally-occurring flavonoids
TLDR
Novel results suggest that certain flavonoids, particularly the flavonols, may prevent collagen breakdown by inhibiting collagenase in inflamed skin as well as photoaged skin.
Inhibition of mammalian collagenase, matrix metalloproteinase-1, by naturally-occurring flavonoids.
TLDR
It is shown, for the first time, that naturally-occurring flavonoids inhibit M MP-1 and down-regulate MMP-1 expression via an inhibition of the AP-1 activation although the cellular inhibitory mechanisms differ depending on their chemical structures.
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