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Anti-inflammatory plant flavonoids and cellular action mechanisms.
The effect of flavonoids on eicosanoid and nitric oxide generating enzymes and the effect on expression of proinflammatory genes are summarized and a potential for new anti-inflammatory agents are discussed.
Anti-inflammatory effects of schisandrin isolated from the fruit of Schisandra chinensis Baill.
Phenolic constituents from the flower buds of Lonicera japonica and their 5-lipoxygenase inhibitory activities.
Effects of sophoraflavanone g, a prenylated flavonoid from sophoraFlavescens, on cyclooxygenase-2 andIn Vivo inflammatory response
Although the potencies of inhibition were far less than that of a reference drug, prednisolone, this compound showed higher antiinflammatory activity when applied topically, suggesting a potential use for several eicosanoidrelated skin inflammation such as atopic dermatitis.
The naturally occurring biflavonoid, ochnaflavone, inhibits LPS-induced iNOS expression, which is mediated by ERK1/2 via NF-kappaB regulation, in RAW264.7 cells.
Anti-inflammatory activity of pectolinarigenin and pectolinarin isolated from Cirsium chanroenicum.
- H. Lim, K. Son, H. Chang, K. Bae, S. Kang, Hyun Pyo Kim
- BiologyBiological & pharmaceutical bulletin
- 1 November 2008
Results suggest that pectolinarigenin and pectolinarin possess anti-inflammatory activity and that they may inhibit eicosanoid formation in inflammatory lesions, and certainly contribute to the anti- inflammatory mechanism of C. chanroenicum.
Biochemical pharmacology of biflavonoids: Implications for anti-inflammatory action
- Hyun Pyo Kim, Haeil Park, K. Son, H. Chang, S. Kang
- Biology, ChemistryArchives of pharmacal research
- 13 April 2008
This work has shown that certain biflavonoids exhibit anti-inflammatory activity through the regulation of proinflammatory gene expression in vitro and in vivo and that these molecules also exhibit cyclooxygenase-2 inhibitory activity.
Inhibition of collagenase by naturally-occurring flavonoids
Novel results suggest that certain flavonoids, particularly the flavonols, may prevent collagen breakdown by inhibiting collagenase in inflamed skin as well as photoaged skin.
Effects of flavonoids on senescence-associated secretory phenotype formation from bleomycin-induced senescence in BJ fibroblasts.
Inhibition of mammalian collagenase, matrix metalloproteinase-1, by naturally-occurring flavonoids.
It is shown, for the first time, that naturally-occurring flavonoids inhibit M MP-1 and down-regulate MMP-1 expression via an inhibition of the AP-1 activation although the cellular inhibitory mechanisms differ depending on their chemical structures.