Hyun-Joon Kim

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Wnt/b-catenin signaling plays a central role in development and is also involved in a diverse array of diseases. Binding of Wnts to the coreceptors Frizzled and LRP6/5 leads to phosphorylation of PPPSPxS motifs in the LRP6/5 intracellular region and the inhibition of GSK3b bound to the scaffold protein Axin. However, it remains unknown how GSK3b is(More)
We propose a new parallel ray-tracing hardware architecture in which processors are connected as a ring. Most parallel ray-tracing algorithms subdivide the whole object space into subregions; A processor handles only rays entering the sub-region assigned to it. Here we assign each processor objects that are spread over the whole object space. The processors(More)
Wnt proteins control diverse biological processes through β-catenin-dependent canonical signalling and β-catenin-independent non-canonical signalling. The mechanisms by which these signalling pathways are differentially triggered and controlled are not fully understood. Dishevelled (Dvl) is a scaffold protein that serves as the branch point of these(More)
Rab3d is a member of the Ras-related small GTPase family of secretory Rab, Rab3. In this study, we showed that Xenopus Rab3d is expressed specifically in the anterior border of the neural plate when the neural plate converges and folds to initiate neural tube formation. Morpholino-mediated knockdown of Rab3d resulted in neurulation defects both in neural(More)
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