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Drug resistance via feedback activation of Stat3 in oncogene-addicted cancer cells.
TLDR
It is found that many drug-treated "oncogene-addicted" cancer cells engage a positive feedback loop leading to Stat3 activation, consequently promoting cell survival and limiting overall drug response, and inhibition of a Stat3 feedback loop may augment the response to a broad spectrum of drugs that target pathways of oncogene addiction. Expand
TRPS1 Targeting by miR-221/222 Promotes the Epithelial-to-Mesenchymal Transition in Breast Cancer
TLDR
The data suggest that combining inhibition of the EGFR-RAS-ERK pathway with standard chemotherapy could, by limiting miR-221/222 production, provide a strategy to combat metastasis in the basal-like subtype of breast cancer. Expand
Analyses of enzyme II gene mutants for sugar transport and heterologous expression of fructokinase gene in Corynebacterium glutamicum ATCC 13032.
TLDR
The fructokinase gene from Clostridium acetobutylicum was expressed in C. glutamicum and resulted in the direct phosphorylation of fructose without any fructose efflux, which may be a potential strategy for enhancing amino acid production. Expand
Tipping the Balance: Sclerotinia sclerotiorum Secreted Oxalic Acid Suppresses Host Defenses by Manipulating the Host Redox Environment
TLDR
Sclerotinia uses a novel strategy involving regulation of host redox status to establish infection and addresses a long-standing issue involving the ability of OA to both inhibit and promote ROS to achieve pathogenic success. Expand
An inhibitor of KDM5 demethylases reduces survival of drug-tolerant cancer cells.
TLDR
Findings show that pretreatment of cancer cells with a KDM5-specific inhibitor results in the ablation of a subpopulation of cancers cells that can serve as the founders for therapeutic relapse. Expand
Trends in parasitic diseases in the Republic of Korea.
TLDR
In the Republic of Korea, cases of zoonotic, opportunistic and imported parasitoses are being detected increasingly and food-borne trematode infections, such as clonorchiasis and intestinal trematodiases, each show steady prevalence. Expand
miR-221/222 Targeting of Trichorhinophalangeal 1 (TRPS1) Promotes Epithelial-to-Mesenchymal Transition in Breast Cancer
TLDR
MiR-221/222 may contribute to the aggressive clinical behavior of basal-like breast cancers because of their targeting of the 3′ untranslated region of TRPS1 (trichorhinophalangeal syndrome type 1), which is a member of the GATA family of transcriptional repressors. Expand
Identification and Characterization of Sclerotinia sclerotiorum NADPH Oxidases
TLDR
It is shown that ROS are essential for the pathogenic development of Sclerotinia sclerotiorum, an economically important fungal pathogen with a broad host range and consistent with the importance of ROS regulation in the successful pathogenesis of S. sclerotsiorum. Expand
A survey of cryptosporidiosis among 2,541 residents of 25 coastal islands in Jeollanam-Do (Province), Republic of Korea.
TLDR
It is indicated that human Cryptosporidium infections are maintained at a relatively low prevalence on coastal islands of Jeollanam-do, Republic of Korea. Expand
Repression of Stress-Induced LINE-1 Expression Protects Cancer Cell Subpopulations from Lethal Drug Exposure.
TLDR
The genomes of a cancer cell subpopulation that survives treatment with otherwise lethal drugs, the drug-tolerant persisters (DTPs), exhibit a repressed chromatin state characterized by increased methylation of histone H3 lysines 9 and 27 (H3K9 and H3K27). Expand
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