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Cyanidin is an agonistic ligand for peroxisome proliferator-activated receptor-alpha reducing hepatic lipid.
  • Y. Jia, J. Kim, +8 authors S. Lee
  • Biology, Medicine
  • Biochimica et biophysica acta
  • 1 April 2013
To investigate the underlying mechanism of targets of cyanidin, a flavonoid, which exhibits potent anti-atherogenic activities in vitro and in vivo, a natural chemical library that identified potentExpand
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The natural carotenoid astaxanthin, a PPAR-α agonist and PPAR-γ antagonist, reduces hepatic lipid accumulation by rewiring the transcriptome in lipid-loaded hepatocytes.
  • Y. Jia, J. Kim, +7 authors S. Lee
  • Biology, Medicine
  • Molecular nutrition & food research
  • 1 June 2012
SCOPE A natural carotenoid abundant in seafood, astaxanthin (AX), has hypolipidemic activity, but its underlying mechanisms of action and protein targets are unknown. We investigated the molecularExpand
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Shikonin induces cell cycle arrest in human gastric cancer (AGS) by early growth response 1 (Egr1)-mediated p21 gene expression.
ETHNOPHARMACOLOGICAL RELEVANCE Lithospermum erythrorhizon, a naphthoquinone compound derived from a shikonin, has long been used as traditional Chinese medicine for treatment of various diseases,Expand
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Induction of apoptosis by genipin inhibits cell proliferation in AGS human gastric cancer cells via Egr1/p21 signaling pathway.
Natural compounds are becoming important candidates in cancer therapy due to their cytotoxic effects on cancer cells by inducing various types of programmed cell deaths. In this study, weExpand
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Complete nucleotide sequence of the temperate bacteriophage LBR48, a new member of the family Myoviridae
The complete genomic sequence of LBR48, a temperate bacteriophage induced from a lysogenic strain of Lactobacillus brevis, was found to be 48,211 nucleotides long and to contain 90 putative openExpand
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Comparative genomic analysis of Lactococcus garvieae phage WP-2, a new member of Picovirinae subfamily of Podoviridae.
To date, a few numbers of bacteriophages that infect Lactococcus garvieae have been identified, but their complete genome sequences have not yet been investigated. For the first time, herein, theExpand
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Chemopreventive Properties of Genipin on AGS Cell Line via Induction of JNK/Nrf2/ARE Signaling Pathway
Roles of dietary phytochemicals in cancer chemoprevention via induction of nuclear factor‐erythroid‐2‐related factor 2 (Nrf2)‐mediated antioxidant enzymes have been well established in a number ofExpand
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Effect of anthocyanins on expression of matrix metalloproteinase-2 in naproxen-induced gastric ulcers.
Non-steroidal anti-inflammatory drugs cause gastric ulceration through a number of mechanisms including inhibition of PG synthesis, generation of reactive oxygen species (ROS) and induction ofExpand
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Complete genomic sequence of the Lactobacillus temperate phage LF1
Bacteriophage LF1, a newly isolated temperate phage from a mitomycin-C-induced lysate of wild type Lactobacillus fermentum, was found to contain a double-strand DNA of 42,606 base pairs (bp) with aExpand
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In vivo and in vitro characterization of site-specific recombination of a novel serine integrase from the temperate phage EFC-1.
EFC-1 integrase is a site-specific recombinase that belongs to the large family of serine recombinase. In previously study, we isolated the temperate phage EFC-1, and characterized its genomicExpand
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