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Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are expressed in the central nervous system and play a regulatory role in neuronal excitability. In the present study, we examined a physiological role of HCN channels in the rat basolateral amygdala (BLA). In vitro electrophysiological studies showed that ZD7288 decreased spontaneous(More)
Up-regulation of adhesion molecules plays an important role in the infiltration of leukocytes into the skin during the development of various inflammatory skin diseases, such as atopic dermatitis. In this study, we investigated the modulatory effects of 2,3-dimethoxy-2'-hydroxychalcone (DMHC) on tumor necrosis factor (TNF)-α-induced intercellular adhesion(More)
Silicon dioxide (SiO2) and zinc oxide (ZnO) nanoparticles are widely used in various applications, raising issues regarding the possible adverse effects of these metal oxide nanoparticles on human cells. In this study, we determined the cytotoxic effects of differently charged SiO2 and ZnO nanoparticles, with mean sizes of either 100 or 20 nm, on the U373MG(More)
Glucocorticoid released by stressful stimuli elicits various stress responses. Acute treatment with a single dose of corticosterone (CORT; predominant glucocorticoid of rats) alone has previously been shown to trigger anxiety behavior and robust dendritic hypertrophy of neurons in the basolateral amygdala (BLA). Neurons in the medial prefrontal cortex(More)
—We propose a unified context-aware augmented reality application framework that supports intelligent guidance and enables users to participate in content generation in museum guidance. It helps a user find personal interesting artifacts in art galleries by exploiting context-based behavior generation. The framework also enables them to combine augmented(More)
The widespread use of smart phones with GPS and orientation sensors opens up new possibilities for location-based annotations in outdoor environments. However, a completely different approach is required for indoors. In this study, we introduce IMAF, a novel indoor modeling and annotation framework on a mobile phone. The framework produces a 3D room model(More)
Independent subspace anlaysis (ISA) is a linear model-based method which generalizes independent component analysis (ICA) by incorporating the invariant feature sub-space into multidimensional ICA. In this paper we apply ISA to the problem of gene expression data analysis and show the useful behavior of the independent subspaces of gene expression data in(More)
The epidemiology of enteroviral infection in South Korea during 1999-2011 chronicles nationwide outbreaks and changing detection and subtyping methods used over the 13-year period. Of 14,657 patients whose samples were tested, 4,762 (32.5%) samples were positive for human enterovirus (human EV); as diagnostic methods improved, the rate of positive results(More)
The selection of dispersion is a classical problem in ecology and evolutionary biology. Deterministic dynamical models of two competing species differing only in their passive dispersal rates suggest that the lower mobility species has a competitive advantage in inhomogeneous environments, and that dispersion is a neutral characteristic in homogeneous(More)
Demographic stochasticity, the random fluctuations arising from the intrinsic discreteness of populations and the uncertainty of individual birth and death events, is an essential feature of population dynamics. Nevertheless theoretical investigations often neglect this naturally occurring noise due to the mathematical complexity of stochastic models. This(More)