Hye-Yeon Im

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Quantum dots (QDs) are novel tools with multiple biological and medical applications because of their superior photoemission and photostability characteristics. However, leaching of toxic metals from QDs is of great concern. Therefore, for the successful application of QDs in bioscience, it is essential to understand their biological fate and toxicity. We(More)
Experimental autoimmune encephalomyelitis (EAE), a Th1 polarized demyelinating disease of the central nervous system, shares many pathological and clinical similarities with multiple sclerosis (MS). The objectives of this study were i) to evaluate the suppressive effects of L-leucinethiol (LeuSH), a metalloprotease inhibitor on EAE-induced mice and ii) to(More)
Tissue distribution and observable-adverse-effect-level of cadmium selenide/cadmium sulfide (CdSe/CdS) quantum dots (QDs) were investigated to get important information of this QDs. Female BALB/c mice were treated with single intravenous (IV) injection of polyethylene glycol-folic acid-coated QDs (CdSe/CdS-PEG-FA) at different concentrations (0, 270, and(More)
Nano-sized materials are increasingly used in cosmetics, diagnosis, imaging, and drug delivery. It also involved in specific functionality with lymphoid systems. However, the toxicity and mechanisms of quantum dots (QDs) uptake into mammalian cells are poorly understood. Our study was to investigate the toxicity and tissue uptake of polyethylene(More)
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