Hye-Lim Noh

Learn More
Uncoupling protein 1 (UCP1) is highly expressed in brown adipose tissue, where it generates heat by uncoupling electron transport from ATP production. UCP1 is also found outside classical brown adipose tissue depots, in adipocytes that are termed 'brite' (brown-in-white) or 'beige'. In humans, the presence of brite or beige (brite/beige) adipocytes is(More)
Low or absent expression of the cyclin-dependent kinase inhibitor p27 Kip1 serves as an excellent malignant marker for prostate and other human cancers. The level of p27 Kip1 is regulated primarily by the ubiq-uitin E3 ligase SCF SKP2 through ubiquitin-dependent proteolysis. Expression of the F-box protein SKP2 is inversely correlated with p27 in many(More)
  • 1