Hye Jin Oh

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Intracellular accumulation of polyglutamine (polyQ)-expanded Huntingtin (Htt) protein is a hallmark of Huntington's disease (HD). This study evaluated whether activation of Sirt1 by the anti-cancer agent, β-lapachone (β-lap), induces autophagy in human neuroblastoma SH-SY5Y cells, thereby reducing intracellular levels of polyQ aggregates and their(More)
BACKGROUND In patients undergoing pituitary surgery using a transsphenoidal approach, anesthesia emergence should be smooth with minimal coughing. Recent studies demonstrated that a target-controlled infusion of remifentanil effectively suppresses coughing induced by the endotracheal tube. We investigated the EC95 of remifentanil for smooth emergence(More)
The effect of light source and DIF (difference between light and dark-period temperatures) on the growth and anthocyanin concentration of Perilla frutescens var. acuta Kudo grown in a growth chamber was examined. The plant was grown under 140 μmol·m−2·s−1 PPF provided by either cool white fluorescent lamps (FL, the control), white (W) light emitting diodes(More)
BACKGROUND Polyglutamine (polyQ)-induced protein aggregation is the hallmark of a group of neurodegenerative diseases, including Huntington's disease. We hypothesized that a protease that could cleave polyQ stretches would intervene in the initial events leading to pathogenesis in these diseases. To prove this concept, we aimed to generate a protease(More)
The objective of this study was to investigate the effect of ionic strength of the nutrient solution on growth and quality of plug seedlings of three indigenous medicinal plant species. Seeds were sown in 200-cell plug trays, containing a commercial medium in a glasshouse. The pH of a nutrient solution supplied was adjusted to 5.96. The electrical(More)
We report a case of a 51-year-old woman with Evans syndrome (autoimmune hemolytic anemia and primary immune thrombocytopenia) and hypothyroidism. She was previously diagnosed with Hashimoto's thyroiditis in 1994 (age, 35) and autoimmune hemolytic anemia (AIHA) 3 years ago. She was treated with oral prednisolone. After a period, in which the anemia waxed and(More)
The study investigated the association between disease activity and serum 25-hydroxyvitamin D3 (25(OH)-D3), B cell activation of the tumor necrosis factor family (BAFF), or β2 microglobulin in patients with primary Sjogren's syndrome (SS). Sixty-nine primary SS patients and 22 sicca control patients were included in the study. Disease activity was measured(More)
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