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Previous studies demonstrated that cytokines regulate opioid and opioid receptor gene expression in neuronal and immune cells. The gene sequence analysis of opioid receptors revealed that mu-, delta- and kappa-opioid receptor promoter regions contain potential cytokine response elements (NF-IL6 binding sites). It was postulated that the response elements(More)
Combination therapy of intravenous immunoglobulin (IVIG) and rituximab showed a good transplant rate in highly sensitized wait-listed patients for deceased donor kidney transplantation (DDKT), but carried the risk of antibody-mediated rejection. The authors investigated the impact of a new combination therapy of bortezomib, IVIG, and rituximab on(More)
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