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GCC-4401C, an orally active direct factor Xa inhibitor that is similar to rivaroxaban, is currently under development for venous thromboembolic disease (VTE). The purpose of this study was to characterize the pharmacokinetics (PKs) and pharmacodynamics (PDs) of GCC-4401C by population modeling analysis and to predict proper dosage regimens compared to(More)
We performed a double-blinded, genotype-based stratification study to explore the pharmacokinetics and pharmacodynamics of amitriptyline according to CYP2C19 and CYP2D6 genotype in Korean subjects. Twenty-four healthy adults were grouped by genotype of CYP2C19 and CYP2D6. After a single dose of 25 mg of amitriptyline, blood samples were collected and(More)
  • Lee Jw, Lee Je, +14 authors P D Hinduja Hospital
induced bilateral acute angle closure glaucoma and transient myopia. Indian annular ciliochoroidal effusion had resolved in both eyes. Anti‑glaucoma medications, a corticosteroid, and cycloplegic eye drops were subsequently discontinued. 3 OS, and angle increased by 13.4° OD and 19.5° OS compared with the measures at the initial visit [Table 1] [Figs. 2c(More)
The combination of solid solution heat treatments and severe plastic deformation by high-ratio differential speed rolling (HRDSR) resulted in the formation of an ultrafine-grained microstructure with high thermal stability in a Mg-5Zn-0.5Zr (ZK60) alloy. When the precipitate particle distribution was uniform in the matrix, the internal stresses and(More)
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